Mechanical and Biological Behaviour of PCL and PCL/PLA Scaffolds for Tissue Engineering Applications

A new biomanufacturing system allowing to produce three-dimensional matrices (scaffolds) with well defined internal geometries, uniform pore distribution and good adhesion among different adjacent layers. Polymers selected are Poly ε-caprolactone (PCL) and Poly Lactic Acid (PLA), both these polymers are used in medical applications. These two polymers are interesting biomaterials because they are complementary on their physical properties and biodegradability. This work aims to assess the temperature evaluation during the extrusion process and the influences of the temperatures on the PCL and PCL/PLA scaffolds with lay down pattern 90o and pore size 350μm. The results demonstrated that extrusion process not modified the thermal properties of the scaffolds and these structures are able to sustain MG-63cells.